Statins may help control multiple sclerosis

Statins may help control multiple sclerosis

Statins may be useful in treating advanced multiple sclerosis (MS), say UK researchers.

Early trial results in The Lancet show the cholesterol-lowering pills slow brain shrinkage in people with MS.

The University College London (UCL) scientists say large trials can now begin.

These will check whether statins benefit MS patients by slowing progression of the disease and easing their symptoms.

MS is a major cause of disability, affecting nerves in the brain and spinal cord, which causes problems with muscle movement, balance and vision.

Currently there is no cure, although there are treatments that can help in the early stages of the disease.

Advanced disease

Usually, after around 10 years, around half of people with MS will go on to develop more advanced disease – known as secondary progressive MS.

It is this later stage disease that Dr Jeremy Chataway and colleagues at UCL hope to treat with low cost statins.

To date, no licensed drugs have shown a convincing impact on this later stage of the disease.

For their phase two trial, which is published in the Lancet, Dr Chataway’s team randomly assigned 140 people with secondary progressive MS to receive either 80mg of a statin called simvastatin or a placebo for two years.

The high, daily dose of simvastatin was well tolerated and slowed brain shrinkage by 43% over two years compared with the placebo.

Dr Chataway said: “Caution should be taken regarding over-interpretation of our brain imaging findings, because these might not necessarily translate into clinical benefit. However, our promising results warrant further investigation in larger phase three disability-driven trials.”

The researchers believe statins may have anti-inflammatory and neuroprotective properties that can guard the nerves from damage.

In an accompanying editorial, Jacqueline Palace from the John Radcliffe Hospital, Oxford, and Neil Robertson from Cardiff University in Wales, said the trial represented a promising starting point in the quest to find a treatment for secondary progressive MS.

Dr Susan Kohlhaas, head of biomedical research at the MS Society, said: “There are no treatments that can stop the condition from worsening in people with progressive MS. Scientists have worked for years to find a potential treatment that could help people, and now, finally, one has been found that might. This is very exciting news.

“Further, larger clinical trials are now absolutely crucial to confirm the safety and effectiveness of this treatment.”

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